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pd_meltingpoint:162-166 °C(lit.)
Appearance:white to light yellow crystal powder
Purity:99%
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4-Amino-3,5-dichloroacetophenone is used to synthesize the drug Clenbuterol. Clenbuterol is a steroid-like chemical that was initially developed to treat asthma in horses, working by relaxing the airways in the animals'lungs.
acetyl chloride
2,6-Dichloroaniline
1-(4-amino-3,5-dichlorophenyl)-1-ethanone
Conditions | Yield |
---|---|
With iron(III) chloride; In chloroform; at 0 - 20 ℃; for 6h;
|
88.6% |
p-aminobenzophenone
1-(4-amino-3-chlorophenyl)ethan-1-one
1-(4-amino-3,5-dichlorophenyl)-1-ethanone
Conditions | Yield |
---|---|
With N-chloro-succinimide; In acetonitrile; at 20 ℃; for 3.5h;
|
80% 18% |
With N-chloro-succinimide; In acetonitrile; at 20 ℃; for 4.5h;
|
20% 45% |
The CAS number of 4-Amino-3,5-dichloroacetophenone is 37148-48-4.
More information of 4-Amino-3,5-dichloroacetophenone 37148-48-4 are:
CAS Number |
37148-48-4 |
Density |
1.386 g/cm3 |
Melting Point |
162-166 °C(lit.) |
Boiling Point |
351.5 °C at 760 mmHg |
Flash Point |
166.4 °C |
Vapor Pressure |
4.1E-05mmHg at 25°C |
Refractive Index |
1.5500 (estimate) |
HS CODE |
29223990 |
PSA |
43.09000 |
LogP |
3.35940 |
Pka |
-1.72±0.10(Predicted) |
Synonyms for 4-Amino-3,5-dichloroacetophenone 37148-48-4:1-(4-Amino-3,5-dichlorophenyl)ethanone;4-Acetyl-2,6-dichloroaniline;1-(4-Amino-3,5-dichlorphenyl)ethanon;4-Amino-3,5-dichloroacetophenone;
The chemical formula of 4-Amino-3,5-dichloroacetophenone is C8H7Cl2NO which containing 8 Carbon atoms,7 Hydrogen atoms,2 Chlorine atoms,1 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight of 4-Amino-3,5-dichloroacetophenone is 204.056.
4-Amino-3,5-dichloroacetophenone is an intermediate in the synthesis of the antitussive and antiasthmatic drug gramtin.
InChI:InChI=1/C8H7Cl2NO/c1-4(12)5-2-6(9)8(11)7(10)3-5/h2-3H,11H2,1H3
Relevant articles related to 4-Amino-3,5-dichloroacetophenone:
Article |
Source |
3,5-dichloro-4-bromoisoquinoline derivative, and preparation method and application thereof |
- Paragraph 0036-0037, (2019/10/04) |
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