What is the drug bexagliflozin used for? Is bexagliflozin available in the USA?

2025.09.11

Bexagliflozin, CAS NO.1118567-05-7, sold under the brand name Brenzavvy, is a prescription medication approved for use in adults with type 2 diabetes. It is designed to be used alongside diet and exercise to improve blood sugar control.

How Bexagliflozin Works

Bexagliflozin belongs to a class of drugs called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It works in the kidneys by blocking a protein called SGLT2. This protein is normally responsible for reabsorbing most of the glucose filtered by the kidneys back into the bloodstream. By inhibiting SGLT2, bexagliflozin prevents this reabsorption, causing excess glucose to be flushed out of the body through urine. This process effectively lowers blood sugar levels.

Because this mechanism of action is independent of insulin, it is particularly useful for treating type 2 diabetes. Beyond lowering blood sugar, this process can also lead to modest weight loss and a reduction in systolic blood pressure.

Uses and Important Limitations

It is crucial to understand that bexagliflozin is approved only for type 2 diabetes. It is not for use in patients with type 1 diabetes, as it can increase their risk of a dangerous condition called diabetic ketoacidosis (DKA).

Is Bexagliflozin Available in the USA?

Yes, bexagliflozin is available in the United States.

The U.S. Food and Drug Administration (FDA) approved Brenzavvy (bexagliflozin) in January 2023 for improving glycemic control in adults with type 2 diabetes.

Availability and Pricing:
A key feature of Brenzavvy is its affordability compared to other medications in its class. It is marketed as a lower-cost alternative and is typically priced at around $50 to $60 for a 30-day supply, often without the need for insurance. It can be purchased through certain online pharmacies like Cost Plus Drugs and DiRx, as well as at some retail pharmacies like Publix.

It's important to note that due to its direct sales model, Brenzavvy may not be available at every local pharmacy. Patients should check with their doctor or the manufacturer's (TheracosBio) website for more information on where to find it.

Common and Serious Side Effects

Common side effects are related to its mechanism of action and include:

• Increased urination

• Genital yeast infections (in men and women)

• Urinary tract infections (UTIs)

Bexagliflozin is also associated with more serious, though less common, risks. These include:

• Diabetic ketoacidosis (DKA)

• Dehydration and low blood pressure

• Acute kidney injury

• A rare, serious genital infection (Fournier's gangrene)

• Hypoglycemia (especially when taken with other diabetes drugs like insulin)

• Increased risk of lower limb amputations (observed with other SGLT2 inhibitors)

Patients should discuss these risks with their healthcare provider, especially if they have kidney problems, liver disease, or consume alcohol frequently.

In Summary

Bexagliflozin (Brenzavvy) is an FDA-approved, oral medication used with diet and exercise to manage blood sugar in adults with type 2 diabetes. It works by helping the kidneys remove excess sugar from the body. It is available in the USA as a more affordable treatment option within the SGLT2 inhibitor class. As with any medication, patients must consult their doctor to see if it is an appropriate and safe choice for their individual health needs.