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10250-27-8

  • Product Name:N-benzyl-2-amino-2-methyl-1-propanol
  • Molecular Formula:C11H17 N O
  • Molecular Weight:179.262
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Product Details

pd_meltingpoint:68-70℃

Purity:99%

Trading Company China Wholesale N-benzyl-2-amino-2-methyl-1-propanol 10250-27-8 In Bulk Supply

  • Molecular Formula:C11H17 N O
  • Molecular Weight:179.262
  • Vapor Pressure:0.000488mmHg at 25°C 
  • Melting Point:68-70℃ 
  • Refractive Index:1.527 
  • Boiling Point:300.8°C at 760 mmHg 
  • PKA:14.55±0.10(Predicted) 
  • Flash Point:109.1°C 
  • PSA：32.26000 
  • Density:1.006g/cm3 
  • LogP:1.93800 

N-benzyl-2-amino-2-methyl-1-propanol (Cas 10250-27-8) Usage

Chemical Properties

Yellow-Orange Solid
Uses N-benzyl-2-amino-2-methyl-1-propanol is a compound that is used in organic synthesis.

Synthesis Reference(s)

Tetrahedron, 44, p. 6801, 1988 DOI: 10.1016/S0040-4020(01)86206-2

InChI:InChI=1/C11H17NO/c1-11(2,9-13)12-8-10-6-4-3-5-7-10/h3-7,12-13H,8-9H2,1-2H3

10250-27-8 Relevant articles

ELECTROREDUCTION OF 2-OXAZOLINES

Ryan, Christopher M.,Kariv-Miller, Essie

, p. 6807 - 6810 (1988)

The cathodic behavior of 2-phenyl-4,4-di...

Structure-based drug design of novel potent and selective tetrahydropyrazolo[1,5-a]pyrazines as ATR inhibitors

Barsanti, Paul A.,Aversa, Robert J.,Jin, Xianming,Pan, Yue,Lu, Yipin,Elling, Robert,Jain, Rama,Knapp, Mark,Lan, Jiong,Lin, Xiaodong,Rudewicz, Patrick,Sim, Janet,Taricani, Lorena,Thomas, George,Xiao, Linda,Yue, Qin

, p. 37 - 41 (2015)

A saturation strategy focused on improvi...

Direct Conversion of N-Alkylamines to N-Propargylamines through C-H Activation Promoted by Lewis Acid/Organocopper Catalysis: Application to Late-Stage Functionalization of Bioactive Molecules

Chan, Jessica Z.,Yesilcimen, Ahmet,Cao, Min,Zhang, Yuyang,Zhang, Bochao,Wasa, Masayuki

supporting information, p. 16493 - 16505 (2020/10/26)

An efficient catalytic method to convert...

HETEROARYL(HETEROCYCLYL)METHANOL COMPOUNDS USEFUL IN THE TREATMENT OF HYPERGLYCAEMIA

-

Page/Page column 59; 60, (2020/10/09)

There is herein provided a compound of f...

HETEROCYCLYL(PHENYL)METHANOL COMPOUNDS USEFUL IN THE TREATMENT OF HYPERGLYCAEMIA

-

Page/Page column 67-68, (2020/10/09)

There is herein provided a compound of f...

Microwave-Assisted CuCl-Catalyzed Three-Component Reactions of Alkynes, Aldehydes, and Amino Alcohols

Chen, Ning,Li, Xiang,Xu, Jiaxi

supporting information, p. 3336 - 3344 (2019/08/28)

A microwave (MW)-assisted three-componen...

10250-27-8 Process route

benzaldehyde
100-52-7

benzaldehyde

2-Amino-2-methyl-1-propanol
124-68-5

2-Amino-2-methyl-1-propanol

2-benzylamino-2-methyl-1-propanol
10250-27-8

2-benzylamino-2-methyl-1-propanol

Conditions
Conditions Yield
benzaldehyde; 2-Amino-2-methyl-1-propanol; In toluene; at 150 ℃; for 2h; Dean-Stark;
With hydrogenchloride; sodium tetrahydroborate; In 1,4-dioxane; ethanol; at 0 ℃; pH=Ca. 2; Dean-Stark;
98%
benzaldehyde; 2-Amino-2-methyl-1-propanol; In dichloromethane; at 20 ℃; for 3h; Molecular sieve;
With methanol; sodium tetrahydroborate; at 20 ℃; for 1h;
96%
benzaldehyde; 2-Amino-2-methyl-1-propanol; In dichloromethane; at 20 ℃; for 3h; Molecular sieve;
With methanol; sodium tetrahydroborate; In dichloromethane; at 20 ℃; for 1h;
96%
With sodium cyanoborohydride; acetic acid; In methanol; Ambient temperature;
81.8%
benzaldehyde; 2-Amino-2-methyl-1-propanol; With toluene-4-sulfonic acid; In benzene; for 4h; Heating / reflux;
With sodium cyanoborohydride; In methanol; at 0 ℃; for 1.5h;
With water; sodium hydrogencarbonate; In methanol;
52%
With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 3h;
 
 
  
(2S)-2-phenylglycinol
20989-17-7

(2S)-2-phenylglycinol

benzaldehyde
100-52-7

benzaldehyde

2-benzylamino-2-methyl-1-propanol
10250-27-8

2-benzylamino-2-methyl-1-propanol

Conditions
Conditions Yield
(2S)-2-phenylglycinol; benzaldehyde; In ethanol; for 6h; Reflux;
With sodium tetrahydroborate; In ethanol; at 20 ℃; for 4h; Cooling with ice;
62%

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