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77614-16-5

  • Product Name:Dermorphin
  • Molecular Formula:C40H50N8O10
  • Molecular Weight:802.885
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Product Details

pd_meltingpoint:157-159 °C

Purity:99%

Buy High Quality lowest price of Dermorphin 77614-16-5 White Crystalline Powder

  • Molecular Formula:C40H50N8O10
  • Molecular Weight:802.885
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:157-159 °C 
  • Boiling Point:1323.8°C at 760 mmHg 
  • PKA:9.83±0.15(Predicted) 
  • Flash Point:754.4°C 
  • PSA：314.05000 
  • Density:1.363g/cm3 
  • LogP:3.98630 

DERMORPHIN ACETATE(Cas 77614-16-5) Usage

Description The analgesic potency of dermorphin is about 280 times higher than that of morphine after intracerebroventricular (icv) injection but comparable to that of morphine after subcutaneous (sc) injection because of its low CNS permeability and bioavailability.

Uses

A mu-opioid receptor agonist

InChI:InChI=1/C40H50N8O10/c1-23(44-37(55)29(41)18-25-9-13-27(50)14-10-25)36(54)46-30(19-24-6-3-2-4-7-24)38(56)43-21-34(52)45-31(20-26-11-15-28(51)16-12-26)40(58)48-17-5-8-33(48)39(57)47-32(22-49)35(42)53/h2-4,6-7,9-16,23,29-33,49-51H,5,8,17-22,41H2,1H3,(H2,42,53)(H,43,56)(H,44,55)(H,45,52)(H,46,54)(H,47,57)/t23-,29+,30+,31+,32+,33+/m1/s1

77614-16-5 Relevant articles

A Blocking Group Scan Using a Spherical Organometallic Complex Identifies an Unprecedented Binding Mode with Potent Activity In Vitro and In Vivo for the Opioid Peptide Dermorphin

Strack, Martin,Bedini, Andrea,Yip, King T.,Lombardi, Sara,Siegmund, Daniel,Stoll, Raphael,Spampinato, Santi M.,Metzler-Nolte, Nils

, p. 14605 - 14610 (2016)

Herein, the selective enforcement of one...

Iodotrichlorosilane as Nα-Z cleaving agent in solid phase synthesis of dermorphin and oxytocin

Sivanandaiah, K. M.,Babu, V. V. Suresh,Renukeshwar, H. C.,Gangadhar, B. P.

, p. 487 - 491 (2007/10/02)

Iodotrichlorosilane, prepared by mixing ...

Structure-Activity Studies of Dermorphin. Synthesis and Some Pharmacological Data of Dermorphin and Its 1-Substiituted Analogues

Darlak, Krzysztof,Grzonka, Zbigniew,Janicki, Piotr,Czlonkowski, Andrzej,Gumulka, S. Witold

, p. 1445 - 1447 (2007/10/02)

Dermorphin and its analogues substituted...

77614-16-5 Process route

Z-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH<sub>2</sub>

Z-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2

dermorphin
77614-16-5

dermorphin

Conditions
Conditions Yield
With formic acid; palladium;
80%
N-(fluoren-9-ylmethoxycarbonyl)glycine
29022-11-5

N-(fluoren-9-ylmethoxycarbonyl)glycine

Fmoc-Pro-OH
71989-31-6

Fmoc-Pro-OH

N-Fmoc L-Phe
35661-40-6

N-Fmoc L-Phe

Fmoc-Ser(tBu)-OH
71989-33-8

Fmoc-Ser(tBu)-OH

Fmoc-Tyr(tBu)-OH
71989-38-3,118488-18-9,204384-67-8

Fmoc-Tyr(tBu)-OH

N-(9-fluorenylmethoxycarbonyl)-D-alanine
35661-38-2,35661-39-3,79990-15-1,136132-75-7

N-(9-fluorenylmethoxycarbonyl)-D-alanine

dermorphin
77614-16-5

dermorphin

Conditions
Conditions Yield
Fmoc-Ser(tBu)-OH; With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; at 20 ℃; for 1h;
With piperidine; In 1-methyl-pyrrolidin-2-one; for 0.333333h;
N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Pro-OH; N-Fmoc L-Phe; Fmoc-Tyr(tBu)-OH; N-(9-fluorenylmethoxycarbonyl)-D-alanine; Further stages;
 

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