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pd_meltingpoint:157-159 °C
Purity:99%
Description | The analgesic potency of dermorphin is about 280 times higher than that of morphine after intracerebroventricular (icv) injection but comparable to that of morphine after subcutaneous (sc) injection because of its low CNS permeability and bioavailability. |
Uses |
A mu-opioid receptor agonist |
InChI:InChI=1/C40H50N8O10/c1-23(44-37(55)29(41)18-25-9-13-27(50)14-10-25)36(54)46-30(19-24-6-3-2-4-7-24)38(56)43-21-34(52)45-31(20-26-11-15-28(51)16-12-26)40(58)48-17-5-8-33(48)39(57)47-32(22-49)35(42)53/h2-4,6-7,9-16,23,29-33,49-51H,5,8,17-22,41H2,1H3,(H2,42,53)(H,43,56)(H,44,55)(H,45,52)(H,46,54)(H,47,57)/t23-,29+,30+,31+,32+,33+/m1/s1
Herein, the selective enforcement of one...
Iodotrichlorosilane, prepared by mixing ...
Dermorphin and its analogues substituted...
Z-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
dermorphin
Conditions | Yield |
---|---|
With formic acid; palladium;
|
80% |
N-(fluoren-9-ylmethoxycarbonyl)glycine
Fmoc-Pro-OH
N-Fmoc L-Phe
Fmoc-Ser(tBu)-OH
Fmoc-Tyr(tBu)-OH
N-(9-fluorenylmethoxycarbonyl)-D-alanine
dermorphin
Conditions | Yield |
---|---|
Fmoc-Ser(tBu)-OH; With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; at 20 ℃; for 1h;
With piperidine; In 1-methyl-pyrrolidin-2-one; for 0.333333h;
N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Pro-OH; N-Fmoc L-Phe; Fmoc-Tyr(tBu)-OH; N-(9-fluorenylmethoxycarbonyl)-D-alanine; Further stages;
|
BOC-glycine
1-(tert-butoxycarbonyl)-L-proline
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine
BOC-O-benzyl-L-serine
N-Acetyl-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
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