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330936-69-1

  • Product Name:humanin
  • Molecular Formula:C119H204 N34 O32 S2
  • Molecular Weight:2801.26
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Product Details

Purity:99%

Good Supplier In Bulk Supply humanin 330936-69-1 in stock

  • Molecular Formula:C119H204 N34 O32 S2
  • Molecular Weight:2801.26
  • PSA：1126.15000 
  • Density:1.43±0.1 g/cm3(Predicted) 
  • LogP:4.77230 

humanin (Cas 330936-69-1) Usage

Description

Humanin is a member of a new family of peptides that are encoded by short open reading frames within the mitochondrial genome.

Uses

Humanin (HN) is a secreted mitochondrial-encoded peptide with neuroprotective effects. It is a mitochondrial-derived peptide, comprises of 24 amino acids, and encoded by a 75-bp ORF. HN protects cells against various diseases, including diabetes mellitus, cardiovascular, and neurodegenerative diseases. HN exerts pro-apoptotic activity of TNF-α in cancer, which makes HN as a novel therapeutic agent.

330936-69-1 Relevant articles

Humanin Is a Novel Neuroprotective Agent Against Stroke

Xingshun Xu, Chu C. Chua, Jinping Gao, Ronald C. Hamdy and Balvin H.L. Chua

, StrokeVol. 37, No. 10

We analyzed infarct size in the cortex and striatum separately to verify whether the protective effect of HNG on infarct volume is similar in these parts of the brain. Overall, Humanin treatment decreased the infarct volume in cortex by 54% and the infarct volume in striatum by 45%. This data indicates that HN reduces infarct size in both cortex and striatum (P<0.01).

Mechanisms of Neuroprotection by a Novel Rescue Factor Humanin from Swedish Mutant Amyloid Precursor Protein

Yuichi Hashimoto a, Yuko Ito a, Takako Niikura a 1, Zongjun Shao a, Michihiro Hata a, Fumitaka Oyama b, Ikuo Nishimoto a 1

, Biochemical and Biophysical Research Communications Volume 283, Issue 2, 4 May 2001, Pages 460-468

We report a novel gene, designated Humanin (HN) cDNA, that suppresses neuronal cell death by K595N/M596L-APP (NL-APP), a mutant causing familial Alzheimer's disease (FAD), termed Swedish mutant.

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