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107868-30-4

  • Product Name:Exemestane
  • Molecular Formula:C20H24O2
  • Molecular Weight:296.409
  • Appearance:white to light yellow crystal powder
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Product Details

pd_meltingpoint:155.13 ºC

Appearance:white to light yellow crystal powder

Purity:99%

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1.What is the Exemestane ?

Labeled Exemestane, intended for use as an internal standard for the quantification of Exemestane by GC- or LC-mass spectrometry.

6-methyleneandrosta-4-ene-3,17-dione
19457-55-7

6-methyleneandrosta-4-ene-3,17-dione

exemestane
107868-30-4

exemestane

Conditions
Conditions Yield
With N,O-Bis(trimethylsilyl)trifluoroacetamide; chloranil; trifluorormethanesulfonic acid; In toluene; at 108 - 110 ℃; for 0.75h; Product distribution / selectivity; Heating / reflux;
81.8%
With trifluorormethanesulfonic acid; N,O-Bis(trimethylsilyl)trifluoroacetamide; chloranil; In toluene; Inert atmosphere; Reflux;
81%
With tert-butyldimethylsilyl chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; at 0 - 20 ℃;
30.2%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; ethyl acetate;
 
With chloranil; In 1-methyl-pyrrolidin-2-one; at 20 - 80 ℃; Product distribution / selectivity;
 
With 2,3-dicyano-5,6-dichloro-p-benzoquinone; salicylic acid; In toluene; at 110 - 115 ℃; Product distribution / selectivity;
 
With Arthrobacter simplex ATCC6946 culture; In aq. buffer; at 33 ℃; Microbiological reaction;
 
With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In toluene; for 5h; Reflux;
 
With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; for 15h; Heating / reflux;
 
6α-hydroxymethylandrosta-1,4-diene-3,17-dione
933455-74-4

6α-hydroxymethylandrosta-1,4-diene-3,17-dione

exemestane
107868-30-4

exemestane

Conditions
Conditions Yield
6α-hydroxymethylandrosta-1,4-diene-3,17-dione; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 30 ℃;
With methanol; potassium hydroxide; at 40 - 50 ℃;
90%

2.What is the CAS number for Exemestane ?

The CAS number of Exemestane is 107868-30-4.

More information of Exemestane 107868-30-4 are:

CAS Number

 107868-30-4

Density

 1.13 g/cm3

Melting Point

 155.13 ºC

Boiling Point

 453.7 ºC at 760 mmHg

Flash Point

 169 ºC

Vapor Pressure

 2.02E-08mmHg at 25°C

Refractive Index

 1.572

HS CODE

 29372900

PSA

 34.14000

LogP

 4.02950

3.What are another words for Exemestane ?

Synonyms for Exemestane 107868-30-4:Exemestane [USAN:INN:BAN];Aromasil;Aromasin;FCE 24304;Exemestane Tablets;Androsta-1,4-diene-3,17-dione, 6-methylene-;Exemestano;Exemestano [INN-Spanish];Exemestanum;Exemestanum [INN-Latin];HSDB 7463;Exemestane;

4.What is the molecular formula of Exemestane?

The chemical formula of  Exemestane is C20H24O2 which containing 20 Carbon atoms,24 Hydrogen atoms and 2 Oxygen atoms,and the molecular weight of  Exemestane is 296.409.

5.What is Exemestane (107868-30-4) used for?

Exemestane was launched in US and other countries for the treatment of estrogendependent tumors and postmenopausal breast cancer. It is a novel steroidal compound structurally related to the natural substrate for the biosynthesis of estrogen, androstanedione, and can be synthesized by methylidenation of androsta-1, 4-dien- 17beta-ol-3-one in 6 position then oxidation of the alcohol function. Exemestane is an irreversible inactivator of the aromatase enzyme system, so inducing in vivo a dose-related sustained suppression of serum estrogen and minimal endocrine activity. It is the first steroidal representative of the third-generation of orally active aromatase inhibitors with a highly potent and selective mechanism of action, displaying good tolerability and safety profile. In rats with DMBA-induced mammary tumors, 10 to 100 mglkg of exemestan administered po twice-daily for 4 weeks resulted in 76 to 88% regression. In women failing anti-estrogen therapy with tamoxifen, this agent has demonstrated high activity in locally advanced or metastatic disease. In addition, it may also have potential for breast cancer prevention.

InChI:InChI=1/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14?,15?,16?,19-,20+/m1/s1

Relevant articles related to Exemestane:

Article

Source

A practical Δ1-dehydrogenation of Δ4-3-keto-steroids with DDQ in the presence of TBDMSCl at room temperature

Chen, Kaixiong,Liu, Chang,Deng, Le,Xu, Guangyu

, p. 513 - 516 (2010)

Preparation method of exemestane

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Paragraph 0010; 0011; 0013, (2018/07/30)

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