Your Location：Home >Products >Chemical Reagents >718-08-1
Purity:99%
Quality products make an important contribution to long-term revenue and profitability. Selling Trading Company Hot Sale Ethyl 3-oxo-4-phenylbutanoate 718-08-1 In Medicine
Ethyl 3-oxo-4-phenylbutanoate is a useful synthetic intermediate. It is used to prepare pyrazolone derivatives as antiprion compounds. It is also used to prepare pyrrolinylaminopyrimidine analogs as inhibitors of AP-1 and NF-κB mediated gene expression.
cycl-isopropylidene malonate
ethanol
phenylacetyl chloride
ethyl 3-oxo-4-phenylbutyrate
| Conditions | Yield |
|---|---|
|
cycl-isopropylidene malonate; phenylacetyl chloride;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 4h;
ethanol;
for 2h;
Heating;
|
88% |
|
cycl-isopropylidene malonate; phenylacetyl chloride;
With
pyridine;
In
dichloromethane;
at 0 - 20 ℃;
for 1.66667h;
ethanol;
for 3h;
Reflux;
|
80% |
|
cycl-isopropylidene malonate; phenylacetyl chloride;
With
pyridine;
In
dichloromethane;
at 0 - 20 ℃;
ethanol;
for 4h;
Further stages.;
Heating;
|
73% |
|
cycl-isopropylidene malonate; phenylacetyl chloride;
With
pyridine;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
ethanol;
for 2h;
Reflux;
|
69% |
|
cycl-isopropylidene malonate; phenylacetyl chloride;
With
pyridine;
In
dichloromethane;
at 0 - 20 ℃;
ethanol;
for 4h;
Reflux;
|
38% |
|
With
pyridine;
In
dichloromethane;
at 0 - 20 ℃;
|
|
|
cycl-isopropylidene malonate; phenylacetyl chloride;
With
pyridine;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
ethanol;
for 2.5h;
Reflux;
|
33.05 g |
|
cycl-isopropylidene malonate; ethanol; phenylacetyl chloride;
With
pyridine;
In
dichloromethane;
at 0 - 20 ℃;
for 5h;
Inert atmosphere;
In
ethanol; dichloromethane;
at 80 ℃;
for 4h;
Inert atmosphere;
|
ethyl potassium malonate
1-chloroacetophenone
ethyl 3-oxo-4-phenylbutyrate
| Conditions | Yield |
|---|---|
|
ethyl potassium malonate;
With
triethylamine; magnesium chloride;
In
tetrahydrofuran;
at 5 - 20 ℃;
for 3h;
1-chloroacetophenone;
In
tetrahydrofuran;
at 5 - 20 ℃;
for 63h;
|
86% |
The CAS number of 3-OXO-4-PHENYL-BUTYRIC ACID ETHYL ESTER is 718-08-1.
More information of 3-OXO-4-PHENYL-BUTYRIC ACID ETHYL ESTER 718-08-1 are:
|
CAS Number |
718-08-1 |
|
Density |
1.091 g/cm3 |
|
Boiling Point |
290.3 °C at 760 mmHg |
|
Flash Point |
123.9 °C |
|
Vapor Pressure |
0.00209mmHg at 25°C |
|
Refractive Index |
1.054-1.059 |
|
HS CODE |
2918300090 |
|
PSA |
43.37000 |
|
LogP |
1.75140 |
|
Pka |
10.49±0.46(Predicted) |
Synonyms for 3-OXO-4-PHENYL-BUTYRIC ACID ETHYL ESTER 718-08-1:4-Phenylacetoacetic acid ethylester;Ethyl 3-keto-4-phenylbutyrate;Ethyl3-oxo-4-phenylbutyrate;Ethyl 3-oxo-4-phenylbutanoate;Acetoaceticacid, 4-phenyl-, ethyl ester (7CI,8CI);3-Oxo-4-phenylbutanoic acid ethylester;4-Phenyl-3-oxobutanoic acid ethyl ester;Ethyl4-phenyl-3-oxobutanoate;Ethyl 3-oxobenzenebutanoate;Ethyl 4-phenylacetoacetate;Ethyl b-oxobenzenebutanoate;NSC 15691;
The chemical formula of 3-OXO-4-PHENYL-BUTYRIC ACID ETHYL ESTER is C12H14O3 which containing 12 Carbon atoms,14 Hydrogen atoms and 3 Oxygen atoms,and the molecular weight of 3-OXO-4-PHENYL-BUTYRIC ACID ETHYL ESTER is 206.241.
InChI:InChI=1/C12H14O3/c1-2-15-12(14)9-11(13)8-10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3
Relevant articles related to 3-OXO-4-PHENYL-BUTYRIC ACID ETHYL ESTER:
|
Article |
Source |
|
Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds |
Pallesen, Jakob S.,Narayanan, Dilip,Tran, Kim T.,Solbak, Sara M. ?.,Marseglia, Giuseppe,S?rensen, Louis M. E.,H?j, Lars J.,Munafò, Federico,Carmona, Rosa M. C.,Garcia, Anthony D.,Desu, Haritha L.,Brambilla, Roberta,Johansen, Tommy N.,Popowicz, Grzegorz M.,Sattler, Michael,Gajhede, Michael,Bach, Anders supporting information, p. 4623 - 4661 (2021/05/07) |
|
Desymmetrization of meso-dicarbonatecyclohexene with β-Hydrazino carboxylic esters via a Pd-catalyzed allylic substitution cascade |
Xu, Kai,Zheng, Yan,Ye, Yong,Liu, Delong,Zhang, Wanbin supporting information, p. 8836 - 8841 (2020/11/30) |
公司英文名称 is a quality supplier of 3-OXO-4-PHENYL-BUTYRIC ACID ETHYL ESTER. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on 3-OXO-4-PHENYL-BUTYRIC ACID ETHYL ESTER 718-08-1.
CAS：119356-77-3
CAS：868844-74-0
CAS：1119-51-3
CAS：56553-60-7
