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80714-61-0

  • Product Name:semax
  • Molecular Formula:C37H51N9O10S
  • Molecular Weight:813.932
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Product Details

Purity:99%

Good Producer Supply High Quality semax 80714-61-0 Global

  • Molecular Formula:C37H51N9O10S
  • Molecular Weight:813.932
  • Vapor Pressure:0mmHg at 25°C 
  • Boiling Point:1335.2°Cat760mmHg 
  • PKA:3.43±0.20(Predicted) 
  • Flash Point:761.3°C 
  • PSA：325.58000 
  • Density:1.391g/cm3 
  • LogP:2.71460 

ACTH (4-7), Pro-Gly-Pro-(Cas 80714-61-0) Usage

Description

Semax is a synthetic analogue of the adrenocorticotropic hormone, a hormone responsible for the production of cortisol which in turn regulates glucose and lipid metabolism and helps to maintain blood pressure. In the hippocampus, Semax rapidly elevates the levels of brain-derived neurotrophic factor (BDNF), a protein important in encouraging growth and differentiation of new neurons and synapses. BDNF is active in the hippocampus, cortex, and forebrain and is important for memory, coordination, concentration, and learning. Semax also works to activate the dopaminergic and serotonergic systems to help prime the brain for action and to induce a controlled state of mental stress.

Uses

Over continued use, guests have seen benefits such as:Reduces anxiety and depression;Improves mental clarity, memory, and focus. Semax has undergone extensive study in Russia and is on the Russian List of Vital & Essential Drugs approved by the Russian Federation government on December 7, 2011. Medical uses for Semax include treatment of stroke, transient ischemic attack, memory and cognitive disorders, peptic ulcers, optic nerve disease, and to boost the immune system.

Mechanism of action

Semax has been prescribed for anxiety, memory improvement, ischemic events, stroke, nerve regeneration, ADHD, opioid withdrawal and even chronic diseases such as ALS, Parkinson’s Disease, and Alzheimer’s. Semax has been known to be used as an Adderall alternative.

InChI:InChI=1/C37H51N9O10S/c1-57-16-13-24(38)32(50)42-25(11-12-31(48)49)33(51)43-26(18-23-19-39-21-41-23)34(52)44-27(17-22-7-3-2-4-8-22)36(54)46-15-5-9-28(46)35(53)40-20-30(47)45-14-6-10-29(45)37(55)56/h2-4,7-8,19,21,24-29H,5-6,9-18,20,38H2,1H3,(H,39,41)(H,40,53)(H,42,50)(H,43,51)(H,44,52)(H,48,49)(H,55,56)/t24-,25-,26?,27-,28-,29-/m0/s1

80714-61-0 Relevant articles

AN ANALOG OF ACTH4-10 - A LONG-ACTION STIMULATOR OF LEARNING

Ponomareva-Stepnaya, M. A.,Nezavibat'ko, V. N.,Antonova, L. V.,Andreeva, L. A.,Alfeeva, L. Yu.,et al.

, p. 445 - 450 (2007/10/02)

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SYNTHESIS OF A HEPTAPEPTIDE FORMING A MODIFIED ACTH 4-10 FRAGMENT

Krysin, E. P.,Karel'skii, V. N.,Rabinovich, A. K.,Borovkova, S. Yu.

, p. 706 - 709 (2007/10/02)

A scheme is given for the synthesis of a...

80714-61-0 Process route

C<sub>50</sub>H<sub>75</sub>N<sub>9</sub>O<sub>12</sub>S
111491-74-8

C50H75N9O12S

H-Met-Glu-His-Phe-Pro-Gly-Pro
80714-61-0

H-Met-Glu-His-Phe-Pro-Gly-Pro

Conditions
Conditions Yield
With dimethylsulfide; trifluoroacetic acid; In various solvent(s); at 30 ℃; for 3h;
88%
Boc-Met-Glu-His-Phe-Pro-Gly-Pro
92411-06-8

Boc-Met-Glu-His-Phe-Pro-Gly-Pro

H-Met-Glu-His-Phe-Pro-Gly-Pro
80714-61-0

H-Met-Glu-His-Phe-Pro-Gly-Pro

Conditions
Conditions Yield
With hydrogenchloride; In acetic acid; for 0.5h; Ambient temperature;
57%

80714-61-0 Upstream products

  • 92411-06-8
    92411-06-8

    Boc-Met-Glu-His-Phe-Pro-Gly-Pro

  • 111491-74-8
    111491-74-8

    C50H75N9O12S

  • 15761-39-4
    15761-39-4

    1-(tert-butoxycarbonyl)-L-proline

  • 1738-78-9
    1738-78-9

    L-phenylalanine benzyl ester p-toluene-sulfonic acid salt

80714-61-0 Downstream products

  • 14517-44-3
    14517-44-3

    L-methionyl-L-glutamic acid

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