pd_meltingpoint:88-90 °C
Appearance:white odourless crystals
Purity:99%
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Benzocaine is used as an anesthetic (Local and topical) that in products such as burn and sunburn remedies, hemorrhoidal creams, suppositories, creams for treatment of poison ivy, oral and gingival products, sore-throat sprays/lozenges, astringents, appetite suppressants, callus and wart remedies, athlete's-foot remedies, toothache- and denture-irritation products.
Ethyl 4-bromobenzoate
4,4'-triazenediyl-di-benzoic acid diethyl ester
diethyl biphenyl-4,4'-dicarboxylate
4,4'-Iminobis(benzoesaeureethylester)
p-aminoethylbenzoate
4,4'-bis(ethoxycarbonyl)azobenzene
Conditions | Yield |
---|---|
With copper(l) iodide; sodium azide; N,N`-dimethylethylenediamine; In dimethyl sulfoxide; at 100 ℃; Inert atmosphere;
|
ethyl 4-nitrobenzoate
p-aminoethylbenzoate
4,4'-bis(ethoxycarbonyl)azobenzene
4,4'-azoxy-di-benzoic acid diethyl ester
Conditions | Yield |
---|---|
With sodium tetrahydroborate; In tetrahydrofuran; water; at 20 ℃; for 3h; Catalytic behavior;
|
84 %Chromat. |
The CAS number of Benzocaine is 94-09-7.
More information of Benzocaine 94-09-7 are:
CAS Number |
94-09-7 |
Density |
1.13 g/cm>3 |
Melting Point |
88-90 °C |
Boiling Point |
310.7 °C at 760 mmHg |
Flash Point |
164.2 °C |
Vapor Pressure |
0.000589mmHg at 25°C |
Refractive Index |
1.5600 (estimate) |
HS CODE |
Oral rat LD50: 3040 mg/kg |
PSA |
52.32000 |
LogP |
2.02670 |
Pka |
2.5(at 25℃) |
Synonyms for Benzocaine 94-09-7:Benzocaine (USP);Benzoicacid, p-amino-, ethyl ester (8CI);(p-(Ethoxycarbonyl)phenylamine;4-(Ethoxycarbonyl)aniline;4-(Ethoxycarbonyl)phenylamine;4-Aminobenzoic acidethyl ester;4-Carbethoxyaniline;Aethoform;Amben ethyl ester;Anaesthan-syngala;Anaesthin;Anesthesine;Benzoak;Benzocaine;Diet Ayds;Ethoform;Ethyl 4-aminobenzoate;Ethyl aminobenzoate;Ethyl p-aminobenzenecarboxylate;Ethyl p-aminophenylcarboxylate;Gingicaine;Identhesin;Keloform;NSC 41531;NSC 4688;Norcain;Norcaine;Ora-jel;Orabase-B;Orthesin;Parathesin;Parathesine;Slim Mint Gum;Solu H;p-(Ethoxycarbonyl)aniline;p-Aminobenzoic acid ethyl ester;p-Carbethoxyaniline;p-Ethoxycarboxylicaniline;
The chemical formula of Benzocaine is C9H11NO2 which containing 9 Carbon atoms,11 Hydrogen atoms,1 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight of Benzocaine is 165.192.
Benzocaine (ethyl p-aminobenzoate) is used topically by itself or in combination with menthol or phenol in nonprescription dosage forms such as gels, creams, ointments, lotions, aerosols, and lozenges to relieve pain or irritation caused by such conditions as sunburn, insect bites, toothache, teething, cold sores or canker sores in or around the mouth, and fever blisters. Benzocaine is a lipophilic local anesthetic agent with a short duration of action. Like most amino ester-type local anesthetics, it is easily hydrolyzed by plasma cholinesterase. Because of its low pKa, however, it is un-ionized under most physiological conditions and, therefore, can only bind to the lipid side of the local anesthetic receptor. It also can easily cross membranes into systemic circulation to cause systemic toxicities. Furthermore, being a PABA derivative, it has similar allergenic properties to procaine and is contraindicated with sulfonamide antibacterial agents.
InChI:InChI=1/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3/p+1
Relevant articles related to Benzocaine:
Article |
Source |
Anesthesin synthesized by hydrogenation of p-nitrobenzoic acid ethyl ester on palladium catalysts |
Abdullaev , p. 45 - 48 (2001) |
Kinetics of the reduction of p-nitrobenzoic acid esters in nanoreactors on the basis of sulfonated polymers |
Al'Tshuler,Shkurenko,Gorlov , p. 372 - 375 (2015) |
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